GW-0742 Powder is a research compound identified as a potent and highly selective agonist of peroxisome proliferator-activated receptor delta, commonly known as PPARβ/δ. It is widely used in laboratory research involving nuclear receptor signaling, metabolic regulation, inflammation, lipid metabolism, and gene-expression pathways.
GW-0742 is supplied as a research-use compound for controlled laboratory and scientific investigations. Research involving this compound may help scientists better understand the biological functions of PPARδ and its role in cellular and metabolic processes.
The referenced technical information identifies GW-0742 as a selective PPARδ agonist with an approximate activity value of 1 nM in the reported PPARδ assay.
Chemical Information
| Property | Details |
|---|---|
| Product Name | GW-0742 Powder |
| Alternative Name | GW0742 |
| Research Category | PPARδ agonist |
| Selleck Catalog Number | S8020 |
| CAS Number | 317318-84-6 |
| Molecular Formula | C₂₁H₁₇F₄NO₃S₂ |
| Molecular Weight | 471.49 g/mol |
| Appearance | Powder |
| Reported Purity | Up to 99.99% for the referenced batch |
| Water Solubility | Insoluble |
| DMSO Solubility | 94 mg/mL |
| Ethanol Solubility | 44 mg/mL |
The molecular formula, molecular weight, CAS number, solubility information, and reported batch purity are based on the referenced supplier documentation.
Mechanism of Action
GW-0742 functions as an activator of PPARβ/δ, a ligand-activated nuclear receptor involved in regulating gene expression. PPARδ is associated with several biological pathways, including:
- Fatty-acid metabolism
- Lipid utilization
- Energy regulation
- Inflammatory signaling
- Cellular differentiation
- Glucose and metabolic homeostasis
- Skeletal-muscle and adipose-tissue research
- Regulation of gene transcription
In laboratory models, activation of PPARδ can influence the expression of genes involved in lipid handling, energy metabolism, and inflammatory responses.
Reported assay data describe GW-0742 as substantially more selective for PPARδ than for PPARα and PPARγ. The referenced data report approximately 1 nM activity at PPARδ, compared with micromolar-range activity values in the cited PPARα and PPARγ cell-based assays.
Research Applications
GW-0742 Powder may be used in controlled laboratory studies involving:
PPARδ Signaling
Researchers use GW-0742 to investigate PPARδ activation and its effects on downstream gene-expression pathways.
Metabolic Research
The compound may be studied in relation to:
- Fatty-acid oxidation
- Lipid metabolism
- Energy expenditure pathways
- Glucose regulation
- Metabolic signaling
- Adipocyte and muscle-cell biology
Inflammation Research
GW-0742 has been examined in experimental models involving inflammatory signaling and the regulation of inflammation-related gene expression.
Cardiovascular and Lipid Research
PPARδ signaling is relevant to research into lipid transport, cholesterol metabolism, reverse cholesterol transport, and vascular biology.
Muscle and Cellular Research
Laboratory studies may use GW-0742 to investigate metabolic changes in skeletal-muscle cells and other experimental cell systems.
Nuclear Receptor Studies
GW-0742 can serve as a research tool for comparing PPARδ activity with the effects of other nuclear-receptor ligands.
Cell-Based Research
The referenced technical material includes research involving several experimental cell models, including:
- CV-1 cells
- HEK293 cells
- C2C12 cells
- N/TERT-1 cells
These models have been used in studies involving reporter assays, receptor activation, gene expression, and cellular responses to PPARδ stimulation.
Reported research has examined the effects of GW-0742 on PPARδ-dependent transcriptional activity and related biological pathways. The compound has also been compared with other PPAR ligands to evaluate receptor selectivity and cellular activity.
Solubility and Preparation
GW-0742 is reported to be insoluble in water. The referenced supplier information lists the following in-vitro solubility values:
| Solvent | Reported Solubility |
|---|---|
| DMSO | 94 mg/mL |
| Ethanol | 44 mg/mL |
| Water | Insoluble |
For laboratory preparation, researchers should consult the current product documentation, solvent compatibility information, and institutional laboratory procedures before preparing stock solutions.
The appropriate solvent, concentration, handling method, and storage conditions should be determined by qualified laboratory personnel according to the requirements of the specific experiment.
Storage and Stability
The referenced supplier documentation recommends storing GW-0742 Powder under controlled conditions.
| Material Form | Reported Storage Guidance |
|---|---|
| Powder | Up to 3 years at −20°C from receipt |
| Stock solution at −80°C | Up to 1 year |
| Stock solution at −20°C | Up to 1 month in solvent |
Storage stability may depend on the solvent, container, exposure to moisture, temperature changes, and laboratory handling practices. Always consult the current product label, safety data sheet, and certificate of analysis for the applicable storage requirements.
Quality and Documentation
Research-grade GW-0742 products should be evaluated using appropriate quality documentation. Depending on the supplier and batch, available documents may include:
- Certificate of Analysis
- Safety Data Sheet
- Nuclear Magnetic Resonance data
- Product data sheet
- Purity information
- Molecular characterization
- Batch identification
- Storage recommendations
The referenced supplier page provides access to product documentation, including COA, NMR, SDS, and technical data resources. Researchers should review the documentation associated with the specific batch being evaluated.
Research-Use Notice
GW-0742 Powder is intended strictly for laboratory research and scientific investigation. It is not intended for human consumption, self-administration, diagnosis, treatment, or prevention of any disease.
This product description does not provide medical advice, therapeutic recommendations, dosage instructions, or protocols for use in humans or animals. All laboratory work should be conducted by qualified personnel in accordance with applicable institutional safety procedures, legal requirements, and relevant research guidelines.
Frequently Asked Questions
What is GW-0742 Powder?
GW-0742 Powder is a research compound used to study PPARβ/δ activation and related metabolic, inflammatory, and gene-expression pathways.
What is the primary target of GW-0742?
The primary reported target is PPARβ/δ, also referred to as PPARδ.
What is the CAS number of GW-0742?
The CAS number is 317318-84-6.
What is the molecular weight of GW-0742?
GW-0742 has a reported molecular weight of 471.49 g/mol.
Is GW-0742 soluble in water?
No. The referenced technical information identifies GW-0742 as insoluble in water. It has reported solubility in solvents such as DMSO and ethanol.
What research areas use GW-0742?
GW-0742 may be used in research involving PPARδ signaling, lipid metabolism, energy regulation, inflammation, nuclear receptors, cellular metabolism, and gene expression.
How should GW-0742 Powder be stored?
The referenced supplier information recommends storing the powder at approximately −20°C. Stock-solution storage depends on the solvent and temperature. Always verify the current product documentation before storage.
Is GW-0742 intended for human use?
No. GW-0742 is intended for laboratory research only and is not intended for human use or self-administration.
What documentation should be reviewed before laboratory use?
Researchers should review the applicable Certificate of Analysis, Safety Data Sheet, product data sheet, purity information, and storage instructions for the specific batch.
Important Notice
The information provided here is for educational and laboratory research purposes only. Product specifications, purity values, storage recommendations, and technical data may vary by supplier and batch. Always verify the current documentation before conducting research.




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